Orally, Hong Hua/Safflower oil is used for reducing the risk of cardiovascular disease and preventing atherosclerosis.
In , Hong Hua/Safflower is used for hyperemia in women and hair growth.
In folk medicine, Hong Hua/Safflower is used orally for fever, tumors, coughs, bronchial conditions, blood stasis, pain, blood invigoration, amenorrhea, painful menses, stimulating menstruation, coronary heart disease, chest pain, traumatic injuries, inducing sweating, as a laxative, purgative, stimulant, antiperspirant, abortifacient, and expectorant.
For food uses, safflower seed oil is used as a cooking oil.
In manufacturing, safflower flower is used to color cosmetics and dye fabrics. Safflower seed oil is used as a paint solvent.